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About the Role
The Oncology Trial Navigator will play a critical role in connecting Signatera patients to life-changing clinical trial opportunities. As a front-line clinical expert, you will be responsible for the end-to-end execution of patient matching workflows—from initial AI-enabled screening to successful enrollment at a clinical trial site.
You will serve as the primary clinical point of contact for external stakeholders, including treating oncologists, principal investigators (PIs), and research coordinators. This role combines deep oncology clinical knowledge with high-touch stakeholder engagement in a fast-scaling, mission-driven environment. You will work closely with the Senior Manager of Oncology Trial Navigation to pilot and refine the navigation service, providing the "on-the-ground" insights necessary to scale this function across the oncology domain.
What You’ll Do
Physician & Site Engagement
Conduct high-volume, structured outreach to oncologists, PIs, and research coordinators regarding trial-eligible patients identified through Natera ’s platforms.
Act as a clinical consultant to research sites, delivering patient eligibility notifications and facilitating seamless referral workflows.
Track patient progression from initial identification through referral and enrollment, ensuring timely follow-up and resolution of site-level bottlenecks.
Trial Matching & Medical Review
Operationalize outputs from Natera ’s AI-enabled trial matching platform to manage a daily priority queue of potential matches.
Perform rigorous clinical reviews, reconciling patient molecular data (e.g., MRD status, biomarkers) and exome results with trial-specific inclusion/exclusion criteria.
Collaborate with the Clinical Product team to provide real-time feedback on matching accuracy, helping to refine AI algorithms and data filters.
Patient & Caregiver Support (as applicable) Provide high-level, empathetic, and compliant education to patients regarding specific clinical trial opportunities and the clinical significance of their molecular results.
Coordinate warm handoffs to site research teams, ensuring patients feel supported and informed throughout the referral process.
Operational Excellence
Maintain meticulous documentation of all outreach and referral activities within CRM and tracking tools.
Contribute to the continuous improvement of Standard Operating Procedures (SOPs).
Participate in cross-functional collaboration with internal partners to optimize the field.
Qualifications
Education & Licensure:
Current, active licensure as a Registered Nurse (RN), Certified Genetic Counselor (CGC), Nurse Practitioner (NP), or Physician Assistant (PA) .
Must maintain licensure in good standing throughout employment.
Board Certification (e.g., OCN, CCRC, or similar) is highly preferred.
A master’s degree in a clinical or scientific field is preferred.
Professional Experience:
3–5 years of oncology clinical experience, with at least 2 years specifically in oncology clinical research (e.g., as a Research Nurse, Coordinator, or Navigator).
Proven experience in patient identification and trial matching services, ideally within a molecular diagnostics or biotech environment.
Experience communicating complex clinical and genomic information to physicians, PIs, and patients.
Clinical Expertise:
Strong clinical knowledge of oncology, with a focus on biomarker-driven therapies and MRD-based clinical trial landscapes.
Expert-level understanding of clinical trial design and the ability to interpret complex inclusion/exclusion criteria.
Technical & Data Proficiency:
Technology Adoption: Ability to quickly master new AI-enabled matching tools and digital health platforms.
Data Literacy: Comfort navigating large clinical datasets and translating patient records into structured eligibility requirements.
Systems Advocacy: Proactive in identifying workflow inefficiencies and suggesting technological or process-based solutions.
Core Competencies:
Exceptional communication and interpersonal skills.
High degree of empathy and professionalism in patient-facing interactions.
Strong organizational skills and follow through discipline.
Bilingual proficiency in English and Spanish preferred.
OUR OPPORTUNITY
Natera ™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.
The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera , you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.
WHAT WE OFFER
Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!
For more information, visit .
Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.
All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.
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